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31 July 2024 : Clinical Research  

Gas Chromatography-Ion Mobility Spectrometry Reveals Acetoin as a Biomarker for Carbapenemase-Producing Klebsiella pneumoniae

Fuxing Li1ABCDEFG, Yunwei Zheng1ABCDEF, Yanhua Liu1BCDF, Chuwen Zhao12BCDF, Junqi Zhu12BCDF, Yaping Hang1BCDF, Youling Fang12BCDF, Longhua Hu1ABCDEFG*

DOI: 10.12659/MSM.944507

Med Sci Monit 2024; 30:e944507

Figure 5 The changes in the content of 3-hydroxy-2-butanone (acetoin) emitted by standard strain at the T2 time point before and after the addition of carbapenemase inhibitors. (A) The pseudo-3D plots of 3-hydroxy-2-butanone (acetoin) contents in standard strains before and after the addition of carbapenase inhibitors. VOCal (version 0.1.3), G.A.S., Shandong HaiNeng Scientific Instrument Co., Ltd., Shandong, China. (B) Comparison of the relative peak volume (semiquantitative) of 3-hydroxy-2-butanone (acetoin) emitted by standard strains before and after the addition of carbapenase inhibitors. The free online tool Chiplot (https://www.chiplot.online). The Mann-Whitney U test was used for pairwise comparison. * P<0.05. R version 4.2.3, The R Foundation, Vienna, Austria. ATCC – American Type Culture Collection; IPM – imipenem; DPA – pyridine-2,6-dicarboxylic acid.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750