Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

Jing Zhao; He Liang; Yanrong Li; Zimeng Xu; Xueqin Li; Lulu Zhao; Mengqian Zhang; Xuehui Duan

doi:10.12659/MSM.945147

11 December 2024 : Review article

Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

Jing Zhao^{AEF 1*}, He Liang^{BF 1}, Yanrong Li^{FG 2}, Zimeng Xu^{B 3}, Xueqin Li^{B 3}, Lulu Zhao^{B 3}, Mengqian Zhang^{B 3}, Xuehui Duan^{B 3}

DOI: 10.12659/MSM.945147

Med Sci Monit 2024; 30:e945147

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Introduction ROS, Free Radicals, and Human Health Antioxidant Intake and Human Health Pathogenesis and Treatment of DILI Oxidative Stress and DILI Antioxidants Are Widely Found in TCM Repair Mechanism of DILI by Antioxidants in TCM Future Directions Conclusions References

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Figure 1 A brief model of drug-induced ROS overproduction in liver cells. In this model, improper drug use (designated in the figure as “abuse”) can stimulate mitochondria and NOX, as well as other mechanisms of ROS production. We classify exogenous drugs that can lead to DILI into 2 categories: modern drugs and TCM, based on whether they consist of single compounds or mixtures. For further details, please refer to the main text. NOX – NADPH oxidase; TCM – Traditional Chinese Medicine; Mit. – mitochondrial, DILI – drug-induced liver injury.

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Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

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