15 November 2024 : Clinical Research
Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Activation and Cytokine Production
Maciej Ołdak1BC, Weronika Kurowska
1DE, Magdalena Plebańczyk1BE, Iwona Janicka1B, Anna Radzikowska 1CE, Urszula Skalska 1AFG, Ewa Kuca-Warnawin 1ABCDEF*
DOI: 10.12659/MSM.945273
Med Sci Monit 2024; 30:e945273
Figure 5 Production of IL-21, IL-22, and IL-23. Concentrations of IL-21 (A, D), IL-22 (B, E), and IL-23 (C, F) detected in the culture supernatants of OA- (n=38) or RA-derived (n=38)ASCs or ASCsTI with CD4+ T cells (A–C) or PBMCs (D–F). Monocultures of ASCs, T cells, and PBMCs served as controls. Data are shown as the median (horizontal line) with interquartile range (IQR, box), lower and upper whiskers (data within 3/2xIQR), and outliers (points) (Tukey’s box). The p values are as follows: * 0.05>p>0.01; ** 0.01>p>0.001; *** p<0.001; **** p<0.0001. ASCsTI – ASCs pretreated with TI. Figure created using GraphPad Prism software version 7, Boston, MA, USA.