15 November 2024 : Clinical Research
Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Activation and Cytokine Production
Maciej Ołdak1BC, Weronika Kurowska
1DE, Magdalena Plebańczyk1BE, Iwona Janicka1B, Anna Radzikowska 1CE, Urszula Skalska 1AFG, Ewa Kuca-Warnawin 1ABCDEF*
DOI: 10.12659/MSM.945273
Med Sci Monit 2024; 30:e945273
Figure 6 Production of IL-35, IL-Rα, galectin 3, and LIF. Concentrations of IL-35 (A, E), IL-Rα (B, F), galectin 3 (C, G), and LIF (D, H) detected in the culture supernatants of OA- (n=21) or RA-derived (n=22) ASCs or ASCsTI with CD4+ T cells (A–D) or PBMCs (E–H). Monocultures of ASCs, T cells, and PBMCs served as controls. Data are shown as the median (horizontal line) with interquartile range (IQR, box), lower and upper whiskers (data within 3/2xIQR), and outliers (points) (Tukey’s box). The p values are as follows: * 0.05>p>0.01; ** 0.01>p>0.001; *** p<0.001; **** p<0.0001. ASCsTI – ASCs pretreated with TI. Figure created using GraphPad Prism software version 7, Boston, MA, USA.