07 April 2025 : Review article
Review of Preclinical and Clinical Studies Supporting the Role of Polydeoxyribonucleotide in the Treatment of Tendon Disorders
Shengyu Luo ABC 1*, Shilin Huang AB 1, Sen Li ABCDEFG 1,2DOI: 10.12659/MSM.945743
Med Sci Monit 2025; 31:e945743
Figure 1 Schematic diagram summarizing the basis of polydeoxyribonucleotide (PDRN) efforts: the healing-promoting effect of PDRN appears to be mediated by the activation of adenosine A2A receptor or the “salvage pathway”. Following tissue injuries, PDRN activates the adenosine A2A receptor, facilitating a more complete tissue regeneration process. On the other hand, it stimulates the salvage pathway to enhance DNA synthesis and repair, resulting in faster tissue regeneration. DNA – deoxyribonucleic acid; DNase – deoxyribonuclease. Created with Adobe Photoshop software version 26.2.