Figure 1 (A–D) Evaluation of left ventricular diastolic function using echocardiography in 2 patients with acromegaly. Figure A and B show normal left ventricular diastolic function in a patient with acromegaly. Figure C and D show diastolic dysfunction of grade 1 in a patient with acromegaly. E/A – the ratio of early diastolic mitral inflow velocity to late diastolic mitral inflow velocity; E/e’ – the ratio of early diastolic mitral inflow velocity to early diastolic mitral annular tissue velocity; e‘sept – early diastolic velocity of the septal mitral annulus; E wave – the peak early diastolic velocity; A wave – the peak velocity of blood flow generated by atrial contraction, Dec T – deceleration time. Microsoft Paint 3D, version 2022, Microsoft Windows 10 Pro.