Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study

Khalid J. Alzahrani

doi:10.12659/MSM.947493

09 June 2025 : Clinical Research

Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study

Khalid J. Alzahrani^{ABCDEFG 1*}

DOI: 10.12659/MSM.947493

Med Sci Monit 2025; 31:e947493

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Figure 1 The poses of metformin molecule binding to the (A) wild-type (B) A307T and (C) N680S of the FSHR structure. Metformin forms a prominent hydrogen bond interaction with glutamic acid at 454 position (Maestro, Schrödinger v11.2).

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Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study

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