Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study

Khalid J. Alzahrani

doi:10.12659/MSM.947493

09 June 2025 : Clinical Research

Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study

Khalid J. Alzahrani^{ABCDEFG 1*}

DOI: 10.12659/MSM.947493

Med Sci Monit 2025; 31:e947493

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Figure 2 The RMSD plot shows considerable fluctuation in their trajectory between 0 and 100 ns that contributes less stability to metformin binding. Wild-Type: black, A307T: Red, and N680S: Gray (GROMACS, 2021).

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Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study

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