09 June 2025 : Clinical Research
Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study
Khalid J. Alzahrani ABCDEFG 1*DOI: 10.12659/MSM.947493
Med Sci Monit 2025; 31:e947493
Figure 4 Radius of gyration (Rg) plot indicates the overall compactness of the protein structure in the FSHR-metformin complex (Wild-Type: black, A307T: Red, and N680S Gray). The metformin-FSHR (N680S) structure has a higher Rg value than the wild and A307T structures in almost all regions of the simulation time. The wild and A307T show a similar Rg value with mild deviation until 75 ns, after which A307T tends to have a similar trajectory as wild-type (GROMACS 2021).