Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review

Xi Yin; Xiaohui Hou; Jian Feng

doi:10.12659/MSM.948226

24 September 2025 : Review article

Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review

Xi Yin^{CDEF 1,2}, Xiaohui Hou^{DEF 1}, Jian Feng^{ADEF 1*}

DOI: 10.12659/MSM.948226

Med Sci Monit 2025; 31:e948226

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Introduction Mechanism of Ferroptosis The Defense Systems Against Ferroptosis Ferroptosis of Lung Epithelial Cells in Pulmonary Diseases Treatment Approaches Targeting Ferroptosis in Lung Epithelial Cells Comparative Insights Across Lung Diseases Future Perspectives Conclusions References

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Figure 2 Ferroptosis of lung epithelial cells in different lung diseasesLung epithelial cell ferroptosis is implicated in the pathogenesis of various respiratory diseases, including chronic obstructive pulmonary disease, asthma, pulmonary infections, acute lung injury, pulmonary fibrosis, and lung cancer. The figure illustrates how ferroptosis contributes to epithelial dysfunction and disease progression in each condition. The figure was drawn using Figdraw (www.figdraw.com).

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Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review

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