15 November 2025 : Review article
Signaling Pathways and Therapeutic Approaches in Post-Myocardial Infarction Fibrosis
Gen Ba ABCDEF 1*, Meiqiong Chen G 1DOI: 10.12659/MSM.949030
Med Sci Monit 2025; 31:e949030
Figure 1 Network of fundamental signaling pathways modulating post-MI fibrosis. MI – myocardial infarction; TGF-β1 – transforming growth factor-β1; PI3K – phosphatidylinositol 3-kinase; AKT – protein kinase B; STAT – signal transducer and activator of transcription; AMPK – AMP-activated protein kinase; Nrf2 – nuclear factor erythroid 2-related factor 2; NF-κB – nuclear factor kappa B; NLRP3 – the nucleotide-binding domain, leucine-rich-repeat family, pyrin domain-containing 3; MAPK – mitogen-activated protein kinase.