03 December 2025 : Clinical Research
Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques
Mehmet Hakan Seyithanoğlu
ABCDEFG 1*, İsmail Yurtsever ABCD 2, Meliha Gundag Papaker DEF 1, Ahmet Serdar Mutluer CDEF 3, Tolga Turan Dundar DEF 4,5, Serkan Kitis ABCEF 1, Kerime Akdur BEF 6, Alpaslan Mayadağlı AEF 6,7
DOI: 10.12659/MSM.949489
Med Sci Monit 2025; 31:e949489
Figure 1 Delivered dose-painting plan (plan 2) with biologically defined sub-volumesTreatment scheme of plan 2 (dose-painted 15–18 Gy; delivered). Images of representative patient with recurrent glioblastoma show biologically defined sub-volumes: aggressive voxels (18 Gy at 50% isodose) and passive tumor (15 Gy).