03 December 2025 : Clinical Research
Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques
Mehmet Hakan Seyithanoğlu
ABCDEFG 1*, İsmail Yurtsever ABCD 2, Meliha Gundag Papaker DEF 1, Ahmet Serdar Mutluer CDEF 3, Tolga Turan Dundar DEF 4,5, Serkan Kitis ABCEF 1, Kerime Akdur BEF 6, Alpaslan Mayadağlı AEF 6,7
DOI: 10.12659/MSM.949489
Med Sci Monit 2025; 31:e949489
Figure 2 Simulated uniform-dose comparator (plan 1)Treatment scheme of simulated plan 1 (uniform 16 Gy; simulated, not delivered), in which the tumor was considered as a single mass of tumor, and 16 Gy (50% isodose) was simulated to be given. This plan was generated only for intra-patient (paired) dosimetric comparison with plan 2 (mean dose, integral dose, and volume of normal brain receiving ≥12 Gy [V12]).