03 December 2025 : Clinical Research
Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques
Mehmet Hakan Seyithanoğlu
ABCDEFG 1*, İsmail Yurtsever ABCD 2, Meliha Gundag Papaker DEF 1, Ahmet Serdar Mutluer CDEF 3, Tolga Turan Dundar DEF 4,5, Serkan Kitis ABCEF 1, Kerime Akdur BEF 6, Alpaslan Mayadağlı AEF 6,7
DOI: 10.12659/MSM.949489
Med Sci Monit 2025; 31:e949489
Figure 3 Baseline permeability map identifies the most aggressive sub-regionPre-stereotactic radiosurgery dynamic contrast-enhanced MRI overlaid on post-contrast T1-weighted images in a recurrent glioblastoma shows region of interest 1 in the upper-medial tumor with volume transfer constant (K-trans)=0.05 min−1 (table and concentration-time curves shown). This voxel-wise permeability information was used, together with magnetic resonance spectroscopy and dynamic susceptibility contrast perfusion-weighted imaging, to define escalation sub-volumes for plan 2. IAUC – initial area under the gadolinium concentration-time curve.