03 December 2025 : Clinical Research
Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques
Mehmet Hakan Seyithanoğlu
ABCDEFG 1*, İsmail Yurtsever ABCD 2, Meliha Gundag Papaker DEF 1, Ahmet Serdar Mutluer CDEF 3, Tolga Turan Dundar DEF 4,5, Serkan Kitis ABCEF 1, Kerime Akdur BEF 6, Alpaslan Mayadağlı AEF 6,7
DOI: 10.12659/MSM.949489
Med Sci Monit 2025; 31:e949489
Figure 4 Post-stereotactic radiosurgery permeability reduction within escalation voxelsFollow-up dynamic contrast-enhanced MRI at approximately 3 months after Gamma Knife stereotactic radiosurgery demonstrates decreased volume transfer constant (K-trans) within the prior escalation sub-region (including region of interest 1), consistent with reduced vascular permeability after dose-painted treatment. Quantitative concentration-time curves and derived metrics are displayed for the same region of interests as in Figure 3. IAUC – initial area under the gadolinium concentration-time curve.