07 November 2025 : Review article
Facial Injectable Fillers in Aesthetic Medicine: Clinical Applications and Safety Strategies
Jie Liu A 1, Ming Gao EF 2, Huilin Hu CF 2, Hanyu Pang
BD 2, Yuyang Liu EF 2, Peng Zhang A 1*
DOI: 10.12659/MSM.949944
Med Sci Monit 2025; 31:e949944
Figure 4 Complications after injection of facial material filling. (A) A 45-year-old woman with skin reaction in left naso-labial fold region after hyaluronic acid (HA) infiltration from dermal fillers. There is an erythematous halo, blisters, and livedo reticularis in the middle third of the left cheek (cited Aesthetic Plast Surg. 2021;45(3):1210–20). (B) Close-up view of ill-demarcated, oval-shaped, and firm nodules on the right infraorbital area (cited Ann Dermatol. 2020;32(6):519–22). (C) A 51-year-old patient developed diffuse bilateral upper lid edema following HA injections in both lateral brows. Bilateral, sequential upper lid biopsy revealed migrated hyaluronic acid filler, which was successfully treated with HA (cited Indian J Plast Surg. 2020;53(3):335–43).