Figure 6 Subgroup analysis of immunological features based on underlying disease trigger. Immunological markers were compared between patients with lymphoma-associated hemophagocytic lymphohistiocytosis (LHLH, n=11) and non-LHLH (n=8). The analysis includes proportions of CD8+ T cells, natural killer (NK) cells, and CD56+ T cells (A), as well as the percentage of perforin-expressing cells within each of these subsets (B). Patients in the LHLH subgroup had a significantly lower proportion of NK cells, compared with the non-LHLH subgroup (P=0.0425). No other significant differences were found between the 2 subgroups (P>0.05). Data are presented as scatter plots with each point representing an individual patient; horizontal lines indicate the median and interquartile range. Statistical significance was determined using the Mann-Whitney U test. Figure created with GraphPad Prism v8.0.