Figure 7 Correlation analysis between immunological and clinical laboratory parameters in 19 patients with secondary hemophagocytic lymphohistiocytosis (sHLH) at diagnosis. Scatter plots show the relationship between immune cell features and clinical markers, where each dot represents an individual patient. A significant positive correlation was found between the proportion of natural killer (NK) cells and plasma fibrinogen levels (A). The analysis also revealed a significant negative correlation between the percentage of perforin expression in CD56+ T cells and serum alanine aminotransferase (ALT) levels (left panel, B), and a significant positive correlation between perforin expression in CD8+ T cells and serum soluble CD25 (sCD25) levels (right panel, B). Correlations were assessed using the Spearman rank correlation coefficient (r). The correlation coefficient (r) and P value are displayed on each plot. Figure created with GraphPad Prism v8.0.