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26 November 2025 : Database Analysis  

Long-Term Outcomes of Anticoagulation Monotherapy Versus Combination Therapy in Atrial Fibrillation Patients with Complex Coronary Artery Disease

Wei-Chieh Lee ABCDG 1,2*, Wei-Ting Chang F 1,2, Chon-Seng Hong B 2, Chih-Hsien Lin B 2, Chun-Yen Chiang ORCID logo B 2, Pei-Chieh Huang B 2, Zhih-Cherng Chen BF 1,2, Jhih-Yuan Shih B 1,2, Hsiu-Yu Fang EF 3,4

DOI: 10.12659/MSM.950655

Med Sci Monit 2025; 31:e950655

Figure 2 Kaplan-Meier Curves for event-free survival between treatment groupsFigure displays Kaplan-Meier survival curves comparing event-free survival between patients receiving oral anticoagulation (OAC) alone (group 1) and those receiving both OAC and antiplatelet therapy (APT) (group 2). Panel A illustrates the composite endpoint – which includes massive gastrointestinal bleeding, stroke, revascularization, and cardiovascular mortality – demonstrating a non-significant trend of worse event-free survival in group 2 (log-rank P=0.06). Panel B focuses specifically on revascularization-free survival, showing a similar trend toward worse outcomes in group 2. Although the difference did not reach statistical significance (log-rank P=0.08), the curve suggests a clinically relevant increase in revascularization events over the follow-up period in patients treated with dual therapy.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750