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06 December 2025 : Clinical Research  

Differences in Prefrontal Cortex Activation Between Predominantly Positive and Negative Symptom Profiles in Schizophrenia: A Functional Near-Infrared Spectroscopy Study

Yudiao Liang CD 1, Heping Jiang BCE 1, Bo Liu AE 1, Jie Liao B 1, Yanping Feng B 1, Ruini He AF 1, Sha Zhang BF 1, Youguo Tan AG 1*

DOI: 10.12659/MSM.950780

Med Sci Monit 2025; 31:e950780

Figure 4 Activation differences are shown between patients with predominantly positive symptoms of schizophrenia (PSZ) and those with predominantly negative symptoms of schizophrenia (NSZ) during the verbal fluency task (VFT). The left panel displays a 2D representation of the activation patterns across multiple channels, with warmer colors (red and orange) indicating higher activation and cooler colors (blue) indicating lower activation. The right panel provides a 3D visualization of the brain, highlighting the specific regions of activation. Channels Ch21 and Ch51 exhibited significant activation differences between the 2 groups, with higher activation observed in the PSZ group. These channels survived FDR correction, indicating robust activation differences. The color bar on the right indicates the scale of activation values, with higher values corresponding to greater activation. This figure highlights the distinct activation patterns in the prefrontal cortex (PFC) between patients with PSZ and NSZ during the VFT.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750