02 December 2025 : Clinical Research
Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy
Jia Wang
ABCDEF 1, Xue-qin Bai ABCDEF 1, Meng Li BCDEF 2,3, Xing-jie Wang BCF 4, Shuo-wen Sun BCF 4, Lei Huang ABCDEFG 3,5, Xu Zhang ACDEF 6,7*, Xin Chen ACDEF 1,8
DOI: 10.12659/MSM.950838
Med Sci Monit 2025; 31:e950838
Figure 3 Spearman correlations of key oxylipin biomarkers with clinical parameters in patients with dilated cardiomyopathy. (A) Color-coded correlation matrix between 6 representative oxylipins and 6 clinical metrics. Red tones denote positive correlations and blue tones denote negative correlations; statistical significance is indicated by asterisks. (B, C) Scatter plots illustrating positive associations of plasma PGE2 level with BNP concentration (r=0.413, P=0.023) and NYHA class (r=0.401, P=0.028), respectively. Linear regression lines and shaded 95% confidence intervals are overlaid to depict correlation strength and variability. BNP – B-type natriuretic peptide; NYHA – New York Heart Association; PGE2 – prostaglandin E2.