02 December 2025 : Clinical Research
Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy
Jia Wang
ABCDEF 1, Xue-qin Bai ABCDEF 1, Meng Li BCDEF 2,3, Xing-jie Wang BCF 4, Shuo-wen Sun BCF 4, Lei Huang ABCDEFG 3,5, Xu Zhang ACDEF 6,7*, Xin Chen ACDEF 1,8
DOI: 10.12659/MSM.950838
Med Sci Monit 2025; 31:e950838
Figure 6 Multivariate SVM modeling of DCM biomarkers. (A) ROC curve for an SVM model trained on the top 20 oxylipins, yielding AUC=0.875. (B) Bar chart of selection frequency for the top 15 metabolites in automated SVM feature ranking. (C) ROC curve for the final 6-marker SVM model (AA_LOX_15-oxo-ETE, AA_LOX_9-HETE, AA_LOX_6R-LXA4, AA_COX_PGE2, AA_P450_16-HETE, EPA_P450_18-HEPE), with AUC=0.876. (D) Confusion matrix of the hold-out validation set, reporting sensitivity of 74.2% and specificity of 75.9%. AUC – area under the curve; DCM – dilated cardiomyopathy; ROC – receiver operating characteristic; SVM – support vector machine.