25 March 2026 : Laboratory Research
ODF3B Promotes the Progression of Clear Cell Renal Cell Carcinoma via the JAK/STAT Signaling Pathway
Yongyang Yun
ABCDEFG 1,2,3,4*, Xing Ji ABCD 1,2,3,4, Tianyu Wu AE 1,2,3,4, Yixiao Liu AE 1,2,3,4, Zheng Li AE 1,2,3,4, Zhoujie Sun AE 1,2,3,4, Peimin Zhou AE 1,2,3,4, Lei Yang AE 1,2,3,4, Wei Yu ABCDEFG 1,2,3,4
DOI: 10.12659/MSM.951100
Med Sci Monit 2026; 32:e951100
Figure 4 (A) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of ODF3B-related differentially expressed genes (DEGs) in ccRCC, highlighting enriched terms, including protein processing in endoplasmic reticulum, endocytosis, apoptosis, and VEGF signaling pathway (representative top pathways are shown). (B) Gene set enrichment analysis (GSEA) demonstrates significant enrichment of the JAK/STAT signaling pathway in the ODF3B-high group compared with the ODF3B-low group. (C–H) Changes in JAK/STAT pathway–related proteins after ODF3B knockdown.