30 January 2026 : Review article
Musculoskeletal Ultrasound and MRI in the Evaluation of Chemotherapy-Induced Peripheral Neuropathy: A Review
Yuxia Zuo BCE 1, Xingchao Xu BC 2, Cai Wu E 2, Xue Cui CE 2, Xiangqi Li A 2*DOI: 10.12659/MSM.951283
Med Sci Monit 2026; 32:e951283
Introduction
Pathogenesis of Chemotherapy-Induced Neuropathy
MSUS Technical Principles and Equipment Selection
Characteristic MSUS Manifestations of CIPN
Quantitative Assessment Parameters of MSUS
Advantages and Limitations of MSUS
Core Technical Principles of MRI (DTI/DKI)
The Correlation Between MRI Features, CIPN Pathology, and Clinical Scales
Quantitative Assessment Parameters of MRI
Limitations and Reproducibility Challenges of MRI
Standardized Protocol for Peripheral Nervous System Examination
Future Directions
Conclusions
References
Figure 5 (A, C) Diffusion kurtosis imaging and diffusion tensor imaging show normal MRI findings of the tibial nerve and common peroneal nerve. (B) It presents with disruption of nerve fiber bundle structure, disappearance of perineural boundaries, and obvious fusiform thickening of the common peroneal nerve. (D) It presents with focal hypointensity along the nerve fiber bundles (indicated by arrows), consistent with the manifestations of axonal injury.