05 May 2026 : Animal Research
RAPTOR Silencing Inhibits Head and Neck Squamous Cell Carcinoma Progression via Regulation of S100A8/A9 and Urokinase Plasminogen Activator
Zhenzhen Fu BCDEF 1,2, Song Wang BCDEF 3, Haoran Zheng BCDEF 2, Huadong Wu BCD 2, Tao Li BCF 2, Lihao Wang BC 2, Hong Li BCF 2, Qiang Zhang AEG 2*DOI: 10.12659/MSM.952169
Med Sci Monit 2026; 32:e952169
Figure 6 Pan-cancer and HNSCC-specific analysis of RAPTOR expression. (A–G) Pan-cancer analyses based on RPTOR mRNA expression across TCGA cohorts. (A) Expression of RPTOR across pan-cancer. (B) Paired analysis of RPTOR expression in tumors versus adjacent normal tissues. (C–F) Correlations of RPTOR expression with immune infiltration (C), tumor microenvironment scores (D), immune checkpoint molecules (E), and immune regulatory genes (F). (G) Association between RPTOR expression and microsatellite instability. (H) RAPTOR protein expression in HNSCC specimens. Representative immunohistochemistry staining showing elevated RAPTOR expression in HNSCC tissues. Scale bar=200 μm. *** P<0.001. HNSCC – head and neck squamous cell carcinoma; TCGA – The Cancer Genome Atlas.