05 May 2026 : Animal Research
RAPTOR Silencing Inhibits Head and Neck Squamous Cell Carcinoma Progression via Regulation of S100A8/A9 and Urokinase Plasminogen Activator
Zhenzhen Fu BCDEF 1,2, Song Wang BCDEF 3, Haoran Zheng BCDEF 2, Huadong Wu BCD 2, Tao Li BCF 2, Lihao Wang BC 2, Hong Li BCF 2, Qiang Zhang AEG 2*DOI: 10.12659/MSM.952169
Med Sci Monit 2026; 32:e952169
Figure 8 Transcriptomic changes and functional enrichment after RAPTOR knockdown. (A, B) Volcano plot and heatmap of DEGs between shNC and shRPTOR Cal27 cells. (C) GO enrichment of DEGs, highlighting significantly enriched biological processes, cellular components, and molecular functions. (D) KEGG pathway enrichment of DEGs. (E, F) GSEA showing downregulation of invasion- and proliferation-related pathways. (G) GSEA highlighting S100A-family gene signatures associated with tumor progression. NES- and FDR-adjusted P values are indicated. DEGs – differentially expressed genes; GO – gene ontology; KEGG – Kyoto Encyclopedia of Genes and Genomes; GSEA – gene set enrichment analysis; NES – normalized enrichment scores; FDR – false discovery rate.