15 April 2026 : Clinical Research
Phospho-Histone H3 as a Tool for Improved Mitotic Counting and Risk Assessment in Gastrointestinal Stromal Tumors: A Study of 241 Cases
Xu LiuDOI: 10.12659/MSM.952182
Med Sci Monit 2026; 32:e952182
Figure 2 Situations likely to be confused with mitotic figures under hematoxylin-eosin staining. (A) The cytoplasm is distinctly eosinophilic. (B) The cell nucleus is large and has a relatively regular shape. (C) The cell nucleus is lobulated, with smooth perinuclear area. (D) The cell nucleus is irregular, the cytoplasm is eosinophilic, the cells around the tumor have poor staining, and there is interstitial mucinous degeneration. (E) Cells in the necrotic area. (F) Nest-like lymphocytes. (G) Impurities that are significantly larger than the surrounding cell nuclei and superimposed on the cell surface. (H) The nucleus is lightly stained, and there are multiple granular chromatins in the nucleus. (I) Proliferated vascular endothelial cells, occasionally irregular cell nucleus morphology, and the cell nucleus is not deeply stained.






