Figure 1 The JAK2/STAT3 signaling pathway regulates Th17 cell differentiation in psoriasisThe Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is a core regulatory pathway for the differentiation of naive CD4+ T cells into T helper 17 (Th17) cells. Its activation initiates the Th17 cell differentiation program, laying an immunological foundation for the occurrence of psoriasis. Interleukin-17 (IL-17) secreted by Th17 cells activates the JAK2/STAT3 signaling pathway in an autocrine manner, further promoting the transcription and expression of IL-17, the Th17 cell-specific transcription factor retinoic acid-related orphan receptor gamma t (RORγt), and the aryl hydrocarbon receptor (AHR). This enhances the pro-inflammatory function of Th17 cells, forming a positive feedback loop of inflammation amplification. Ultimately, it accelerates the pathological development of psoriasis by driving the skin inflammatory cascade reaction. (Created with BioRender.com).