22 April 2026 : Review article
Role of the STAT3 Signaling Pathway in Cell Proliferation and Inflammation in Psoriasis and Approaches for Targeted Therapies: A Review
Limin Li CE 1, Lu Chen B 1, Cai Zhang BEF 2, Wenchao Yao D 1, Zhengxiao Li G 3, Faming Tian G 1,2*DOI: 10.12659/MSM.952449
Med Sci Monit 2026; 32:e952449
Figure 2 The JAK2/STAT3 pathway mediates a pro-inflammatory feedback loop between Th17 cells and dendritic cellsThe activation of the JAK2/STAT3 signaling pathway in Th17 cells can promote the secretion of pro-inflammatory factors, which in turn activates the JAK2/STAT3 signaling pathway in dendritic cells (DCs), mediating the release of chemokines and recruiting neutrophils to aggregate, amplifying the skin inflammatory response. Interleukin-23 (IL-23) secreted by DCs can bind to the surface receptors of Th17 cells and activate their JAK2/STAT3 pathway, forming an inflammatory positive feedback loop between DCs and Th17 cells, continuously driving the progression of psoriasis inflammation. (Created with BioRender.com).