22 April 2026 : Review article
Role of the STAT3 Signaling Pathway in Cell Proliferation and Inflammation in Psoriasis and Approaches for Targeted Therapies: A Review
Limin Li CE 1, Lu Chen B 1, Cai Zhang BEF 2, Wenchao Yao D 1, Zhengxiao Li G 3, Faming Tian G 1,2*DOI: 10.12659/MSM.952449
Med Sci Monit 2026; 32:e952449
Figure 3 Inhibition of the JAK2/STAT3 pathway promotes an anti-inflammatory macrophage phenotypeActivation of the JAK2/STAT3 signaling pathway can promote the polarization of M2-type macrophages to the pro-inflammatory M1 phenotype, and by enhancing the secretion of pro-inflammatory factors by M1-type macrophages, it can drive the progression of psoriasis-related inflammatory responses. Inhibiting the JAK2/STAT3 signaling pathway can induce the polarization of M1-type macrophages to the anti-inflammatory M2 phenotype, reduce the release of pro-inflammatory factors, and thereby alleviate skin inflammatory responses. (Created with BioRender.com).