10 July 2026 : Clinical Research
Effect of Low-Dose Vonoprazan on Hepatic Cytochrome P450 Activity By 13C-Aminopyrine Breath Test in Healthy Subjects
Satoru Takahashi ABCDE 1, Mihoko Yamade ABCDF 1*, Takahisa Furuta A 2, Tomohiro Higuchi AB 3, Mikihiro Shimizu CD 4, Keisuke Inagaki B 1, Kiichi Sugiura B 1, Tomoharu Matsuura B 5, Natsuki Ishida
B 1, Takanori Yamada B 6, Moriya Iwaizumi F 5, Yasushi Hamaya B 1, Ken Sugimoto F 1, Satoshi Osawa DF 6,7
DOI: 10.12659/MSM.953332
Med Sci Monit 2026; 32:e953332
Figure 2 Comparison of area under the curve (AUC) of DOB between control and VPZ conditions at each time intervalPaired raincloud plots illustrating [13C]-ABT cumulative recovery (AUC of DOB,%dose/h) under control and VPZ conditions across different time intervals. (A) 0–3 h, (B) 0–1 h, (C) 1–2 h, (D) 2–3 h. Each panel combines half-violin distributions (orange), central boxplots (black), and paired data (blue × and connecting lines) for visualization of distribution and individual changes. All comparisons were performed using the Wilcoxon signed-rank test (n = 19). No significant difference was observed between 2 conditions. NS, not significant.