10 July 2026 : Clinical Research
Effect of Low-Dose Vonoprazan on Hepatic Cytochrome P450 Activity By 13C-Aminopyrine Breath Test in Healthy Subjects
Satoru Takahashi ABCDE 1, Mihoko Yamade ABCDF 1*, Takahisa Furuta A 2, Tomohiro Higuchi AB 3, Mikihiro Shimizu CD 4, Keisuke Inagaki B 1, Kiichi Sugiura B 1, Tomoharu Matsuura B 5, Natsuki Ishida
B 1, Takanori Yamada B 6, Moriya Iwaizumi F 5, Yasushi Hamaya B 1, Ken Sugimoto F 1, Satoshi Osawa DF 6,7
DOI: 10.12659/MSM.953332
Med Sci Monit 2026; 32:e953332
Figure 3 Comparison of area under the curve (AUC) 0–3h of DOB between control and VPZ conditions by sexAUC of DOB (%dose/h) stratified by gender (Male: n = 10; Female: n = 9). In female subjects, VPZ administration was associated with a statistically significant increase in DOB AUC (Wilcoxon signed-rank test, W = 5, P = 0.039). No significant difference was observed in males (P = 0.846). Each panel combines half-violin distributions (orange), central boxplots (black), and paired data (blue × and connecting lines) for visualization of distribution and individual changes. NS, not significant.