Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 May 2003

Effects of 5-AIQ on the multiple organ failure associated to thermal injury in the rat

M. Caneira, B. Sepodes, R. Pinto, H. Mota-Filipe, C. Thiemermann

Med Sci Monit 2003; 9(1): 7-0 :: ID: 14992

Abstract

Thermal injury initiates a systemic inflammatory response resulting (among others) in the formation of reactive oxygen species (ROS), which may contribute to DNA injury [1]. One possible way of ROS-induced injury involves the excessive activation of poly-(ADP-ribose) polymerase (PARP). The aim of this study was to investigate the effect of the water-soluble inhibitor of PARP, 5-aminoisoquinoline (5-AIQ) on the circulatory and multiple organ failure in rats with thermal injury.Male Wistar rats (300–350 g) were divided in three groups: Control, burn (B) and burn-treated (BT) with 5-AIQ (3 mg/kg i.p., 1 minute after burn and every 2 h). The rats in groups B and BT received a 60% total body surface area scald burn (70°C during 30 seconds) under general anaesthesia, which was maintained until the end of the experiment. Rats were sacrificed 6 h after the injury and blood samples were collected immediately before sacrifice. Determination of serum biochemical markers of liver injury (AST and ALT) and renal dysfunction (urea and creatinine) was done. Mean arterial blood pressure (MAP) was determined every 30 min. Burned animals shown a significant and progressive decrease in MAP towards the end of 6 h experiment, and this hypotension was unaffected by 5-AIQ. Burn induced a significant increase on the serum levels of AST, ALT, urea and creatinine. This multiple organ injury/dysfunction was significantly attenuated by 5-AIQ. Thus, administration of 5-AIQ immediately after a 60% scald burn attenuated the dysfunction and liver injury, but not the circulatory failure associated with severe burn injury.References: 1.Martin D, Lewington A, Hammerman M, Padanilam B: Inhibition of poly (ADP-ribose) polymerase attenuates ischemic renal injury in rats. Am J Physiol Regulatiry Integrative Comp Physiol, 2000; 279: 1834-40

Keywords: thermal injury, Burn, PARP, 5-aminoisoquinoline, Rat

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750