01 March 1996
Med Sci Monit 1996; 2(2): CR183-186 :: ID: 499563
Activation of fibrinolysis resulting in bleeding was observed in patients with prostatic carcinoma. The aim of this study was to estimate the level of plasminogen, a precursor of plasmin and α2,-antiplasmin, its main inhibitor. Blood samples were obtained from 20 patients with prostatic carcinoma and benign prostatic hyperplasia. In three patients with carcinoma massive haematuria was observed. α2,-antiplasmin activity in patients with carcinoma was found to be lower than that in patients with benign prostatic hyperplasia. Plasminogen level in both groups was normal. Additionally, routine fibrinolysis parameters were evaluated which proved to be normal except for the bleeding patients. Apart from the decreased α2,-antiplasmin activity and plasminogen level, the latter group showed a reduced euglobulin lysis time (ELT), increased level of fibrin degradation products (FDP), prolonged kaolin-kephalin time (aPTT) and low platelet count. The altered values of the parameters are, presumably, the evidence of the activation of fibrinolysis. The authors believe that patients with prostatic carcinoma are at higher risk of developing bleeding that those with benign prostatic hyperplasia.
Keywords: prostatics carcinoma, Fibrinolysis, alpha2-antiplasmin, bleeding
01 February 2023 : EditorialEditorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread
Med Sci Monit 2023; 29:e939580
19 January 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
06 Feb 2023 : Clinical ResearchDouble C-Arm Digital Subtraction Angiography Guidance During Transjugular Intrahepatic Portosystemic Shunt ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938912
06 Feb 2023 : Review articleEvolution of Hybrid Intelligence and Its Application in Evidence-Based Medicine: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.939366
03 Feb 2023 : Clinical ResearchTreatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...
Med Sci Monit In Press; DOI: 10.12659/MSM.938865
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292