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21 June 2011

Gastric pH and motility in a porcine model of acute lung injury using a wireless motility capsule

Stefan RauchABCDE, Ralf M. MuellenbachABF, Amelie JohannesBCD, Bernd ZollhoferBCD, Norbert RoewerAE

DOI: 10.12659/MSM.881841

Med Sci Monit 2011; 17(7): BR161-164

Abstract

Background: Evaluation of gastric pH and motility in a porcine model of acute lung injury using a novel, wireless motility capsule.
Material/Methods: A motility capsule was applied into the stomach of 7 Pietrain pigs with acute lung injury induced by high volume saline lavage. Wireless transmission of pH, pressure and temperature data was performed by a recorder attached to the animal’s abdomen. Gastric motility was evaluated using pH and pressure values, and capsule location was confirmed by autopsy.
Results: Gastric pH values were statistically significantly different (P<0.003) in the animals over time and ranged from 1.15 to 9.94 [5.73±0.47 (mean ±SD)] with an interquartile range of 0.11 to 2.07. The capsule pressure recordings ranged from 2 to 4 mmHg [2.6±0.5 mmHg (mean ±SD)]. There was no change in pressure patterns or sudden rise of pH >3 pH units during 24 hours. All animals had a gastroparesis with the capsules located in the stomach as indicated by the pressure and pH data and confirmed by necropsy.
Conclusions: The preliminary data show that Pietrain pigs with acute lung injury have a high variability in gastric pH and severely disturbed gastric motility.

Keywords: Hydrogen-Ion Concentration, Monitoring, Physiologic - methods, Gastrointestinal Motility - physiology, Gastric Emptying - physiology, Capsule Endoscopy - methods, Acute Lung Injury - physiopathology, Sus scrofa

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750