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01 August 2011

Lack of association between the c.544G>A polymorphism of the heme oxygenase-2 gene and age-related macular degeneration

Daniel WysokinskiCDE, Ewelina SynowiecBCF, Marta ChmielewskaBCF, Katarzyna WozniakAD, Małgorzata ZarasBCD, Anna SklodowskaBCF, Janusz BlasiakADEG, Jerzy SzaflikADEG, Jacek Pawel SzaflikADEG

DOI: 10.12659/MSM.881906

Med Sci Monit 2011; 17(8): CR449-455

Abstract

Background: Age-related macular degeneration (AMD) is a primary cause of blindness among the elderly in developed countries. The nature of AMD is complex and includes both environmental and hereditary factors. Oxidative stress is thought to be essential in AMD pathogenesis. Iron is suggested to be implicated in the pathogenesis of AMD through the catalysis of the production of reactive oxygen species, which can damage the retina. Heme oxygenase-2 is capable of degradation of heme producing free iron ions, thus, diversity in heme oxygenase-2 gene may contribute to AMD. In the present work we analyzed the association between the c.544G>A polymorphism of the heme oxygenase-2 gene (HMOX2) (rs1051308) and AMD.
Material/Methods: This study enrolled 276 AMD patients and 105 sex- and age-matched controls. Genotyping of the polymorphism was performed with restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR) on DNA isolated from peripheral blood.
Results: We did not find any association between the genotypes of the c.544G>A polymorphism and the occurrence of AMD. This lack of association was independent of potential AMD risk factors: tobacco smoking, sex and age. Moreover, we did not find any association between AMD and smoking in our study population.
Conclusions: The results suggest that the c.544G>A polymorphism of the heme oxygenase-2 gene is not associated with AMD in this Polish subpopulation.

Keywords: Macular Degeneration - genetics, Heme Oxygenase (Decyclizing) - genetics, Genotype, Aged, 80 and over, Poland, Polymorphism, Single Nucleotide

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