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22 August 2011

The concentration of thiobarbituric acid reactive substances (TBARS) and paraoxonase activity in blood of patients with osteoarthrosis after endoprosthesis implantation

Dorota M. Olszewska-SłoninaABCDE, Dariusz MątewskiBDEF, Rafał CzajkowskiCEF, Krzysztof J. OlszewskiBDEF, Alina WoźniakG, Grażyna Odrowąż-SypniewskaDF, Kinga LisDF, Dariusz MusiałkiewiczEF, Bogna KowaliszynC

DOI: 10.12659/MSM.881936

Med Sci Monit 2011; 17(9): CR498-504

Abstract

Background: The aim of this study was to evaluate the concentration of malondialdehyde (MDA) in erythrocytes and in blood plasma and the activity of blood paraoxonase (PON1) of patients with osteoar¬throsis (OA) submitted to endoprosthesis implantation for evaluating oxidative stress.
Material/Methods: Study was conducted on 55 patients with OA and on 54 total movement-efficient volunteers. The material for the study was venous blood plasma, serum and erythrocytes.
Results: Increased concentration of MDAe before surgery was observed in the group of men and in patients with a degenerative process affecting hip joints. After an implantation of endoprosthesis, MDAe de¬creased to the level observed in the control groups. In the study group MDA concentration in plas¬ma was slightly lower before surgery, and after an operation it reached the value of the parameter of the reference groups. Regardless of sex or age, paraoxonase activity was almost twice as high in almost all subgroups as in the reference group. A positive correlation between PON 1 activity and MDAe concentration was demonstrated both before and after surgery in the group of men.
Conclusions: The increase of PON1 activity in patients’ serum in relation to the control groups indicates a probable pathogenic role of the increased formation of reactive oxygen species in the course of OA and may suggest acute inflammation of the synovial joint. The high level of PON 1 activity after endoprosthe¬sis implantation indicates that surgical treatment may additionally stimulate ROS generation. MDAe concentration indicate more intensive process of lipid peroxidation in the elderly.

Keywords: Osteoarthritis - blood, Malondialdehyde - blood, Erythrocytes - metabolism, Case-Control Studies, Aryldialkylphosphatase - blood, Prosthesis Implantation, Thiobarbituric Acid Reactive Substances - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750