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01 February 2012

Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study

Xian-Bao ZhanAE, Xiao-Rong GuoE, Zhao-Shen LiAG, Yan-Fang GongB, Jun GaoB, Zhuan LiaoF, Zhen LiD, Shen GaoD, Pei LiuC

DOI: 10.12659/MSM.882468

Med Sci Monit 2012; 18(2): CR125-130

Abstract

Background: Until now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity. The aim of this study is to compare the effect of lansoprazole (30 mg) and pantoprazole (40 mg) administered intravenously on gastric acidity.
Material/Methods: Helicobacter pylori-negative healthy volunteers were recruited in this open-label, randomized, two-way crossover, single centre study. Lansoprazole at 30 mg or pantoprazole at 40 mg was intravenously administered twice daily for 5 consecutive days with at least a 14-day washout interval. Twenty-four-hour intragastric pH was continuously monitored on days 1 and 5 of each dosing period.
Results: Twenty-five volunteers completed the 2 dosing periods. The mean intragastric pH values were higher in subjects treated with lansoprazole than those with pantoprazole on both day 1 (6.41±0.14 vs. 5.49±0.13, P=0.0003) and day 5 (7.09±0.07 vs. 6.64±0.07, P=0.0002). Significantly higher percentages of time with intragastric pH >4 and pH >6 were found in the subjects treated with lansoprazole than those with pantoprazole on day 1 (pH >4, 87.12±4.55% vs. 62.28±4.15%, P=0.0012; pH >6, 62.12±4.12% vs. 47.25±3.76%, P=0.0216) and pH >6 on day 5 (76.79±3.77% vs. 58.20±3.77%, P=0.0025).
Conclusions: Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole.

Keywords: Hydrogen-Ion Concentration, Gastric Acid, DNA Primers, Cross-Over Studies, Base Sequence, Anti-Ulcer Agents - administration & dosage, 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage, Infusions, Intravenous, lansoprazole, Polymerase Chain Reaction, Reference Values

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750