23 April 2012
The prevalence of metabolic risk factors among outpatients with diagnosed nonalcoholic fatty liver disease in LithuaniaJonas ValantinasBDEF, Daiva Asta ApanavicieneADEG, Ligita MarozieneCDEF, Audrius SveikataDE
Med Sci Monit 2012; 18(5): PH57-62
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease; there is growing evidence that it is a hepatic manifestation of a metabolic syndrome. This study aimed to assess the prevalence of metabolic risk factors among patients with NAFLD.
Material/Methods: Outpatients with NAFLD were recruited into the study. Family physicians recorded patients’ demographic and anthropometric data, leisure-time physical activity, concomitant diseases, and pharmacological treatment for NAFLD into standardized Case Report Forms.
Results: In total, data on 798 patients were analyzed. Most patients were women and they were older than the men (mean age, 60.2±9.6 vs. 54.5±11.4 years; p<0.05). Metabolic risk factors (obesity, arterial hypertension, dyslipidemia) were highly prevalent in the study patients, and these factors were more prevalent among women. There were no differences in the mean Body Mass Index (BMI), in the proportion of men or women with BMI >30 kg/m2 or central obesity in the 2 age groups (≤60 years and >60 years). Hypertension and diabetes were more prevalent among older men and women. Dyslipidemia was more common among older women. The level of leisure-time physical activity was lower in women and in older patients. The most frequently prescribed pharmacological agents were cytoprotective agents, lipid-lowering drugs, and antioxidants.
Conclusions: Metabolic risk factors were highly prevalent among patients with NAFLD. Obesity, hypertension, and dyslipidemia were more prevalent among women. The differences in the prevalence of hypertension seemed to be influenced by older age of women.
Keywords: Metabolic Syndrome X - epidemiology, Lithuania - epidemiology, Fatty Liver - metabolism, Prevalence, Risk Factors
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