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05 July 2013

Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis

Fariba AlmassinokianiABDEFG, Abolfazl MehdizadehBDF, Elahe SaririBDF, Mansour RezaeiCDE, Alireza AlmasiABDEFG, Hossein AkbariABDEFG, Abdolreza PazookiABDEFG, Masoud Solaymani-DodaranCDE, Sara AsadollahBDF, Jila AmirkhaniBDF, Shahla ChaichianBDF, Mansoureh VahdatBDF, Ashrafsadat MoosaviBDF, Monir AshouriBDF, Zeinab TamannaeiBDF

DOI: 10.12659/MSM.883967

Med Sci Monit 2013; 19:534-539

Abstract

Background
To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
Material and Methods
Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses.
Results
Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05).
Conclusions
Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis.

Keywords: Marital Status, Laparoscopy - adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use, Endometriosis - surgery, Pain, Postoperative - prevention & control, Recurrence, Simvastatin - therapeutic use

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750