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11 September 2013 : Original article  

The evaluation of prevalence of fibromyalgia in patients with chronic urticaria

Mahmut YenerABCDEFG, Ijlal ErturanCD, Ali Murat CeyhanDE, Esra Erkol InalEF, Oya Oylum Kozano─čluB

DOI: 10.12659/MSM.889626

Med Sci Monit 2013; 19:757-761

Abstract

BACKGROUND: The pathophysiology of chronic idiopathic urticaria (CIU) is not fully understood; however, it has been hypothesized that a subset of people with CIU may have an autoimmune disease and that peripheral cutaneous nerve fibers may be involved in CIU. Similarly, it has been postulated that fibromyalgia syndrome (FMS) is an autoimmune disorder and may be associated with alterations of peripheral cutaneous nerve fibers. Accordingly, the present study aimed to determine whether the frequency of FMS is higher in patients with CIU.

MATERIAL AND METHODS: A total of 72 patients with CIU and 67 sex- and age-matched healthy controls were included. Urticaria activity score (UAS), fibromyalgia impact questionnaire (FIQ), tender point number, and visual analogue scale (VAS) were assessed.

RESULTS: The frequency of FMS was similar between the groups (9.7% vs. 4.5%, p=0.32). However, symptom duration of FMS was significantly longer, and tender point number and FIQ were significantly higher in patients with CIU than in controls. In addition, patients with CIU had significantly higher VAS scores. UAS was significantly correlated with presence of FMS, symptom duration of FMS, tender point number, and FIQ and VAS scores. Logistic regression analysis revealed that UAS was an independent predictor of presence of FMS (b=0.34, p=0.003).

CONCLUSIONS: Frequency of FMS was slightly, but not significantly, higher in patients with CIU than in controls. However, symptom duration of FMS, tender point number, and FIQ and VAS scores were significantly higher in patients with CIU, and UAS reflecting severity of the disease was significantly and independently associated with presence of FMS.

Keywords: Case-Control Studies, Area Under Curve, Fibromyalgia - epidemiology, Logistic Models, Prevalence, Questionnaires, ROC Curve, Urticaria - pathology, visual analog scale

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Editorial

01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750