10 January 2014 : Original article
Role of KIR genes and genotypes in susceptibility to or protection against hepatitis B virus infection in a Turkish cohort
Filiz KibarABCDEFG, Ozlem Goruroglu OzturkACDEF, Aslıhan UluBDE, Eren ErkenDE, Seza InalBE, Suzan DinkciC, Behice KurtaranBE, Yesim TasovaEF, Hasan Salih Zeki AksuBE, Akgun YamanACDEFDOI: 10.12659/MSM.889893
Med Sci Monit 2014; 20:28-34
Abstract
BACKGROUND: Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activating receptors expressed by natural killer (NK) cells and regulate NK cell activity in the innate response against viral infections. The aim of this study was to determine the possibility of KIR genes and genotypes as a candidate for susceptibility to or protection against chronic hepatitis B virus (HBV) infection or spontaneous remission of the infection in a Turkish cohort.
MATERIAL AND METHODS: The present study was carried out on 37 patients with chronic HBV infection, 36 patients in spontaneous remission of HBV infection, and 85 healthy subjects. Sequence-specific oligonucleotide probes analysis was used to investigate 16 KIR genes. All data were statistically analyzed by the Fisher exact test.
RESULTS: The rate of inhibitory KIR2DL3 (p=0.0) and 3DS1 (p=0.0) were higher in the healthy group than the group composed of chronic HBV patients and patients with spontaneous remission. There were no statistically significant differences between the rate of AA and Bx genotypes of chronic HBV patients and patients with spontaneous remission and the control group (p>0.05).
CONCLUSIONS: Our results suggest that KIR2DL3 and KIR3DS1 genes could be protector genes for HBV infection and they could be important immuno-genetic markers in determining antiviral immunity in the Turkish population.
Keywords: Case-Control Studies, Cohort Studies, Genetic Markers - genetics, Genetic Predisposition to Disease - genetics, Genotype, Hepatitis B - immunology, Oligonucleotide Probes - genetics, Receptors, KIR - genetics, Turkey
Editorial
01 November 2024 : Editorial
Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and PrognosisDOI: 10.12659/MSM.947038
Med Sci Monit 2024; 30:e947038
In Press
Review article
Epigenetic and Immune Mechanisms Linking Breastfeeding to Lower Breast Cancer RatesMed Sci Monit In Press; DOI: 10.12659/MSM.945451
Clinical Research
Comprehensive Analysis of Immune Infiltration and Key Genes in Peri-Implantitis Using Bioinformatics and Mo...Med Sci Monit In Press; DOI: 10.12659/MSM.941870
Clinical Research
High-Resolution Anorectal Manometry and Balloon Expulsion Test Outcomes in Functional Constipation: A Compa...Med Sci Monit In Press; DOI: 10.12659/MSM.944599
Clinical Research
Plaque Removal and Gingival Bleeding Using Biodegradable Toothbrushes: Salvadora persica, Bamboo, and Nylo...Med Sci Monit In Press; DOI: 10.12659/MSM.944469
Most Viewed Current Articles
17 Jan 2024 : Review article 6,157,120
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,908,619
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 695,167
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 260,369
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074