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22 April 2014 : Original article  

Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction

Ahmet TemizADF, Emine GaziABCDE, Ömer GüngörBEF, Ahmet BarutçuBCF, Burak AltunCEF, Adem BeklerBD, Emine BinnetoğluCF, Hacer ŞenCD, Fahri GüneşEF, Sabri GaziBC

DOI: 10.12659/MSM.890152

Med Sci Monit 2014; 20:660-665

Abstract

BACKGROUND: Platelet-to-lymphocyte ratio (PLR) is a new prognostic marker in coronary artery disease. We aimed to evaluate the relationship between PLR and in-hospital mortality in patients with ST-elevated acute myocardial infarction (AMI).

MATERIAL AND METHODS: The present study included 636 patients with ST-elevated AMI. The study population was divided into tertiles based on their admission PLR. Patients having values in the third tertile was defined as the high PLR group (n=212) and those having values in the lower 2 tertiles were defined as the low PLR group (n=424).

RESULTS: Risk factors of coronary artery disease and treatments administered during the in-hospital period were similar between the groups. Male patient ratio was found to be lower in the high PLR group (73% vs. 82.8%, p=0.004). In-hospital mortality was increased in the high PLR group when compared to the low PLR group (12.7% vs. 5.9%, p=0.004). The PLR >144 was found to be an independent predictor of in-hospital cardiovascular mortality (HR: 2.16, 95% CI: 1.16–4.0, p=0.014).

CONCLUSIONS: This study showed that PLR is an independent predictor of cardiovascular mortality in patients with ST-elevated AMI.

Keywords: Blood Platelets - pathology, Electrocardiography, Hospital Mortality, Lymphocytes - pathology, Myocardial Infarction - physiopathology, ROC Curve, Risk Factors

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750