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26 July 2014 : Review article  

Surgical Management of Early Endometrial Cancer: An Update and Proposal of a Therapeutic Algorithm

Francesca FalconeBE, Giancarlo BalbiCF, Luca Di MartinoBF, Flavio GrausoBF, Maria Elena SalzilloEF, Enrico Michelino MessalliACD

DOI: 10.12659/MSM.890478

Med Sci Monit 2014; 20:1298-1313

Abstract

In the last few years technical improvements have produced a dramatic shift from traditional open surgery towards a minimally invasive approach for the management of early endometrial cancer. Advancement in minimally invasive surgical approaches has allowed extensive staging procedures to be performed with significantly reduced patient morbidity. Debate is ongoing regarding the choice of a minimally invasive approach that has the most effective benefit for the patients, the surgeon, and the healthcare system as a whole. Surgical treatment of women with presumed early endometrial cancer should take into account the features of endometrial disease and the general surgical risk of the patient. Women with endometrial cancer are often aged, obese, and with cardiovascular and metabolic comorbidities that increase the risk of peri-operative complications, so it is important to tailor the extent and the radicalness of surgery in order to decrease morbidity and mortality potentially derivable from unnecessary procedures. In this regard women with negative nodes derive no benefit from unnecessary lymphadenectomy, but may develop short- and long-term morbidity related to this procedure. Preoperative and intraoperative techniques could be critical tools for tailoring the extent and the radicalness of surgery in the management of women with presumed early endometrial cancer. In this review we will discuss updates in surgical management of early endometrial cancer and also the role of preoperative and intraoperative evaluation of lymph node status in influencing surgical options, with the aim of proposing a management algorithm based on the literature and our experience.

Keywords: Endometrial Neoplasms - surgery, Disease Management, Algorithms, Lymph Node Excision - standards, Minimally Invasive Surgical Procedures - trends, Robotic Surgical Procedures - trends, Tumor Markers, Biological

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Editorial

01 January 2023 : Editorial  

Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939357

Med Sci Monit 2023; 29:e939357

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750