Abstract

BACKGROUND: Some studies have evaluated the association between the Ubiquilin 1 (UBQLN1) gene UBQ-8i polymorphism and Alzheimer’s disease (AD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of this association.

MATERIAL AND METHODS: Case-control studies were identified by searching databases of PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang, and VIP. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.

RESULTS: The UBQ-8i polymorphism was significantly associated with an increased AD risk (OR=1.15; 95%CI 1.05–1.25; P=0.002). The combination of adjusted ORs also found UBQ-8i polymorphism was significantly associated with AD risk (OR=1.15; 95%CI 1.02–1.30; P=0.02). When stratified by APOE ε4 status, both APOE ε4 carriers and APOE non-ε4 carriers with UBQ-8i polymorphism had significantly increased AD risk (OR=1.28; 95%CI 1.05–1.56; P=0.01 and OR=1.25; 95%CI 1.04–1.50; P=0.02). In the subgroup analysis according to age, UBQ-8i polymorphism was significantly associated with LOAD risk (OR=1.17; 95%CI 1.05–1.31; P=0.005), but not with EOAD risk (OR=1.12; 95%CI 0.95–1.31; P=0.17).

CONCLUSIONS: These results suggest that the UBQ-8i polymorphism is associated with AD risk.

Keywords: Aged, 80 and over, Alzheimer Disease - genetics, Carrier Proteins - genetics, Case-Control Studies, Cell Cycle Proteins - genetics, Genetic Predisposition to Disease, Polymorphism, Genetic, Risk Factors