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15 December 2014 : Original article  

Intercellular Adhesion Molecule-1 K469E Polymorphism and Risk of Coronary Artery Disease: A Meta-Analysis

Shengqiang ZouAE, Xin PanABCDEF, Zhigang ChenCD, Chao WeiCF, Bin HeBC, Heng ZhangBC

DOI: 10.12659/MSM.891235

Med Sci Monit 2014; 20:2677-2682

Abstract

BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been implicated in susceptibility to coronary artery disease (CAD). Several studies investigated the association of this polymorphism with CAD in different populations but the results were contradictory. A meta-analysis was conducted to assess the association between ICAM-1 K469E polymorphism and CAD susceptibility.

MATERIAL AND METHODS: Databases including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used.

RESULTS: Fifteen case-control studies including 3088 cases and 3466 controls were included. Overall, a significant association between ICAM-1 K469E polymorphism and CAD was observed in the dominant model (OR=1.80; 95% CI 1.62–2.01; P<0.00001; Pheterogeneity=0.40). In subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.92; 95% CI 1.51–2.43; P<0.00001; Pheterogeneity=0.98) and among Caucasians (OR=1.64; 95% CI 1.30–2.08; P<0.0001; Pheterogeneity=0.04). In the subgroup analysis by age, a significant association was found among young patients (OR=1.46; 95% CI 1.10–1.93; P=0.008; Pheterogeneity=0.21) and old patients (OR=1.92; 95% CI 1.75–2.10; P<0.00001; Pheterogeneity=0.99).

CONCLUSIONS: Results of this meta-analysis suggest that ICAM-1 K469E polymorphism confers a risk factor of CAD.

Keywords: Genetic Predisposition to Disease, Coronary Artery Disease - genetics, Intercellular Adhesion Molecule-1 - genetics, Polymorphism, Single Nucleotide - genetics, Publication Bias, Risk Factors

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750