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03 March 2015 : Laboratory Research  

miR-630 Overexpression in Hepatocellular Carcinoma Tissues is Positively Correlated with alpha-Fetoprotein

Jian-wen ZhangABCDE, Yang LiBD, Xian-Cheng ZengCD, Tong ZhangBD, Bin-Sheng FuD, Hui-Min YiC, Qi ZhangB, Nan JiangABCDEG

DOI: 10.12659/MSM.892515

Med Sci Monit 2015; 21:667-673


BACKGROUND: MicroRNA-630 (miR-630) has been shown to be involved in various human malignancies. However, its role in hepatocellular carcinoma (HCC) remains unknown.

MATERIAL AND METHODS: TaqMan qRT-PCR assay was performed to detect the expression of miR-630 in 42 pairs of HCC tissues and corresponding noncancerous hepatocellular tissues, and its correlations with clinicopathologic features and serum alpha-fetoprotein (AFP) level of patients were analyzed.

RESULTS: The present study found that miR-630 expression was significantly increased in HCC tissues and cells compared with their normal counterparts. miR-630 expression level did not significantly chang at stage I but was markedly increased at advanced TNM stage (stage II~III). In addition, the increased expression of miR-630 in tissues of HCC appeared in patients who exhibited elevated serum levels of AFP (>25 ng/ml), but not in those with normal AFP levels (≤25 ng/ml). The miR-630 expression in carcinoma tissues revealed a positive correlation with the levels of serum alpha-fetoprotein (AFP; R2=0.768).

CONCLUSIONS: These results suggest that miR-630 is associated with tumor progression of hepatocellular carcinoma and may be a potential prognosis indicator.

Keywords: Carcinoma, Hepatocellular - genetics, alpha-Fetoproteins - metabolism

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Med Sci Monit 2024; 30:e944204


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750