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27 February 2015 : Meta-Analysis  

CD95 rs1800682A/G Variant and Tumor Risk in Asians: Evidence from a Meta-Analysis of 36 Case-Control Studies Containing 22 438 Samples

Cheng JinAB, Xiaomin WuCD, Yuanlong GuA, Fenglai YuanA, Qinghai YeA, Feng DaiCD, Lijie ZhuEF, Yuanyuan MiAB

DOI: 10.12659/MSM.892547

Med Sci Monit 2015; 21:630-637


Background: The CD95 gene plays a key role in regulating cell growth and tumor genesis. To date, several publications have focused on the CD95 rs1800682A/G site polymorphism and various types of tumors in Asians; however, this association is still controversial and obscure. Therefore, a meta-analysis combined with all publications to clarify this association is necessary.
Material/Methods: A search in the PubMed and SinoMed databases was performed to detect all relevant included publications. Odds ratio (OR) and 95% confidence intervals (CI) revealed association strengths.
Results: Overall, 36 case-control studies were chosen based on the search criteria. There was no association of the CD95 rs1800682A/G site polymorphism with tumor risk in total and ethnicity subgroup analysis. However, further stratified analysis in the cancer subgroup revealed weakly significant associations in hepatocellular carcinoma (AA+AG vs. GG: OR=0.93, 95% CI=0.87–0.99, P=0.035; AG vs. GG: OR=0.89, 95% CI=0.80–0.99, P=0.036).
Conclusions: The CD95 rs1800682A/G site polymorphism may be associated with hepatocellular carcinoma susceptibility. Further large-scale and well-designed studies regarding tumor types and ethnicities are still required to confirm our results.

Keywords: Asian Continental Ancestry Group - genetics, Antigens, CD95 - genetics, Case-Control Studies, Genetic Predisposition to Disease, Neoplasms - genetics, Polymorphism, Single Nucleotide - genetics, Publication Bias, Risk Factors

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Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750