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28 February 2015 : Clinical Research  

The Prognostic Significance of Src and p-Src Expression in Patients with Osteosarcoma

Chao HuABCDEF, Zhouming DengBC, Yi ZhangBD, Lei YanBG, Lin CaiADF, Jun LeiF, Yuanlong XieB

DOI: 10.12659/MSM.892803

Med Sci Monit 2015; 21:638-645

Abstract

BACKGROUND: The expression of Src and phospho-Src (p-Src) is closely related to tumor invasion and metastasis. The aim of the present study was to investigate the expression of these molecules in osteosarcoma and their relationship with each other, to provide a theoretical basis to understand the prognosis of osteosarcoma.

MATERIAL AND METHODS: We selected surgically resected osteosarcoma specimens from 116 patients of Zhongnan Hospital of Wuhan University and Hubei Cancer Hospital, Hubei, China, between January 2000 and January 2010 with detailed follow-up data. Twenty osteochondroma specimens from the corresponding period were used as controls. Expression of Src and p-Src was detected in osteosarcoma and osteochondroma by immunohistochemistry. We analyzed the relationship of the 2 proteins and osteosarcoma patient prognosis.

RESULTS: The expression of Src and p-Src in osteosarcoma was significantly higher than the expression level in osteochondroma (P<0.05). The expression levels of the 2 proteins, clinical stage, and tumor metastasis were significantly associated with survival time (P<0.05), but there was no correlation between age or sex and survival time. The expression of Src and p-Src in osteosarcoma was positively correlated.

CONCLUSIONS: Src and p-Src can be used as an auxiliary indicator to determine a malignant phenotype of bone tumors, and the combined detection of Src and p-Src may indicate the prognosis of osteosarcoma.

Keywords: Adolescent, Bone Neoplasms - surgery, Child, Multivariate Analysis, Osteochondroma - surgery, Osteosarcoma - surgery, Phosphorylation, Postoperative Care, Prognosis, Proto-Oncogene Proteins pp60(c-src) - metabolism, young adult

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750