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13 May 2015 : Clinical Research  

Peripheral Blood Stem Cell Transplantation Improves Liver Functional Reserve

Ting CaiABCDEG, Qinzhi DengABCD, Shun ZhangBCD, Airong HuBCF, Qinghai GongDEF, Xingfen ZhangBEF

DOI: 10.12659/MSM.892990

Med Sci Monit 2015; 21:1381-1386

Abstract

BACKGROUND: Currently available treatment options for decompensated hepatitis B-induced liver cirrhosis are limited and largely ineffective. Recently, stem cell transplantation has emerged as a promising treatment for cirrhosis. The aim of this study was to determine whether autologous peripheral blood stem cell transplantation can improve liver functional reserve in patients with hepatitis B-induced cirrhosis.

MATERIAL AND METHODS: In this study, 51 patients with hepatitis B-induced liver cirrhosis were assigned to the treatment group (n=23) or the control group (n=28). The treatment group underwent autologous peripheral blood stem cell transplantation in addition to comprehensive medical treatment, and the control group received comprehensive medical treatment alone. Liver functional reserve was monitored for 48 weeks after autologous peripheral blood stem cell transplantation.

RESULTS: After transplantation, most patients showed improvements in symptoms such as fatigue, anorexia, and abdominal distension. The retention rate of indocyanine green at 15 minutes, a common indicator of liver functional reserve, declined from 41.99±4.68 at baseline to 37.79±3.75 by 48 weeks after transplantation, showing significant improvement.

CONCLUSIONS: Autologous peripheral blood stem cell transplantation can improve several markers of liver health and liver functional reserve and is a promising prospect for clinical application.

Keywords: Anorexia - etiology, biomarkers, Fatigue - etiology, Fluorescent Dyes - pharmacokinetics, Follow-Up Studies, Granulocyte Colony-Stimulating Factor - pharmacology, Hematopoietic Stem Cell Mobilization, Hepatitis B, Chronic - complications, Indocyanine Green - pharmacokinetics, Liver - physiopathology, Liver Cirrhosis - therapy, Liver Failure - prevention & control, Liver Function Tests, Peripheral Blood Stem Cell Transplantation, Symptom Assessment, Transplantation, Autologous

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750